Over 600 labs worldwide use SCENITH™. Featured in 40+ publications, including Nature, Science Immunology, and Nature Communications.
2025
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.
Denk D, Singh A, Kasler HG, D'Amico D, Rey J, Alcober-Boquet L, Gorol JM, Steup C, Tiwari R, Kwok R, Argüello RJ, Faitg J, Sprinzl K, Zeuzem S, Nekljudova V, Loibl S, Verdin E, Rinsch C, Greten FR. Nat Aging. 2025 Nov;5(11):2309-2322. doi: 10.1038/s43587-025-00996-x. Epub 2025 Oct 31. PMID: 41174221 Free PMC article. Clinical Trial.
Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation.
Li Q, de Oliveira Formiga R, Puchois V, Creusot L, Ahmad AH, Amouyal S, Campos-Ribeiro MA, Zhao Y, Harris DMM, Lasserre F, Ellero-Simatos S, Guillou H, Huang Z, Brot L, Hu Y, Chollet L, Danne C, Scandola C, Ledent T, Chevreux G, Argüello RJ, De Carvalho Bittencourt M, Bettinger J, D'Aveni-Piney M, Moulin D, Schreiber S, Aden K, Rolhion N, Michel ML, Wai T, Sokol H. Nat Metab. 2025 Oct 21. doi: 10.1038/s42255-025-01396-6. Online ahead of print. PMID: 41120706
Single-cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions.
Karra L, Finger AM, Shechtman L, Krush M, Meng-Yao Huang R, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. Blood Adv. 2025 Oct 14;9(19):4996-5008. doi: 10.1182/bloodadvances.2024014411. PMID: 40737538 Free PMC article.
Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation.
de Oliveira Formiga R, Li Q, Zhao Y, Campos Ribeiro MA, Guarino-Vignon P, Fatouh R, Dubois L, Creusot L, Puchois V, Amouyal S, Alonso Salgueiro I, Bredon M, Chollet L, Ledent T, Scandola C, Auger JP, Danne C, Krönke G, Tkacz E, Emond P, Chevreux G, Pham HP, Pontoizeau C, Lamaziere A, Argüello RJ, Rolhion N, Michel ML, Wai T, Sokol H. Cell Host Microbe. 2025 Nov 12;33(11):1855-1872.e10. doi: 10.1016/j.chom.2025.09.009. Epub 2025 Sep 30. PMID: 41033313
Distinct metabolic profiles of circulating plasmacytoid dendritic cells in systemic sclerosis patients stratified by clinical phenotypes.
Ferreira BH, Mazeda C, Dourado E, Simões JL, Prata AR, Argüello RJ, Duarte IF, Pierre P, Almeida CR. Arthritis Res Ther. 2025 Feb 19;27(1):35. doi: 10.1186/s13075-025-03500-3. PMID: 39972361 Free PMC article.
A Single-Cell Methodology for Energy Metabolism Analysis in Parasitic Protozoa.
Vilchez-Larrea SC, Argüello RJ, Alonso GD. Methods Mol Biol. 2026;2982:339-351. doi: 10.1007/978-1-0716-4848-3_22. PMID: 41182628
L-Phenylalanine is a metabolic checkpoint of human Th2 cells.
Kulkarni AJ, Rodriguez-Coira J, Stocker N, Radzikowska U, García-Cívico AJ, Delgado Dolset MI, Contreras N, Jardón Parages I, Saiz Sanchez V, Serrano P, Izquierdo E, Gomez-Casado C, Sanchez-Solares J, Pablo-Torres C, Obeso D, Moreno-Aguilar C, Espinazo ML, Eljaszewicz A, Koch J, Baerenfaller K, Heider A, Tan G, Zhakparov D, Escribese MM, Ruiz-Leon B, Akdis CA, Argüello RJ, Barber D, Villaseñor A, Sokolowska M. Cell Rep Med. 2025 Nov 26:102466. doi: 10.1016/j.xcrm.2025.102466. Online ahead of print. PMID: 41308641
Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling.
Alonso S, Kaur H, Jia L, Nguyen MU, Laguerta A, Fong A, Skariah N, Argüello RJ, Verzi MP, Swamy M, Lau KS, Edelblum KL. Mucosal Immunol. 2025 Oct;18(5):1184-1198. doi: 10.1016/j.mucimm.2025.07.005. Epub 2025 Jul 17. PMID: 40683453 Free PMC article.
Sustained Macrophage Reprogramming Is Required for CD8+ T cell-Dependent Long-Term Tumor Eradication.
Jardim C, Bica M, Reis-Sobreiro M, Teixeira da Mota A, Lopes R, Pinto MF, Sousa NS, Mensurado S, Boekhoff H, Scolaro T, Reugebrink M, Goncalves-Sousa N, Kubo H, Gomes CM, Brito C, Argüello RJ, Leites EP, Morais VA, Silva-Santos B, Barbosa-Morais NL, Serre K. Cancer Immunol Res. 2025 Aug 1;13(8):1207-1225. doi: 10.1158/2326-6066.CIR-24-0797. PMID: 40471151
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions.
Kao YS, Lauterbach M, Lopez Krol A, Distler U, Godoy GJ, Klein M, Argüello RJ, Boukhallouk F, Vallejo Fuente S, Braband KL, Nurbekova A, Romero M, Mamareli P, Silva L, Damasceno LEA, Rampoldi F, Berod L, Lynch L, Hiller K, Sparwasser T. Nat Metab. 2025 May;7(5):966-984. doi: 10.1038/s42255-025-01276-z. Epub 2025 May 13. PMID: 40360755 Free PMC article.
Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer.
Slattery K, Yao CH, Mylod E, Scanlan J, Scott B, Crowley JP, McGowan O, McManus G, Brennan M, O'Brien K, Glennon K, Corry E, Treacy A, Argüello RJ, Gardiner CM, Haigis MC, Brennan DJ, Lynch L. Sci Immunol. 2025 May 9;10(107):eadr4795. doi: 10.1126/sciimmunol.adr4795. Epub 2025 May 9. PMID: 40344087
2024
Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice
Gallerand A, Dolfi B, Stunault MI, et al. Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice. (Impact factor: 16.6)
Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling
Borelli A, Santamaria JC, Zamit C, et al. Lymphotoxin limits Foxp3+ regulatory T cell development from Foxp3lo precursors via IL-4 signaling. Nature Communications. 2024. (Impact factor: 16.6)
Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis
Maio M, Barros J, Joly M, et al. Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis. (Impact factor: 8.1)
Dependence on mitochondrial respiration of malignant T cells reveals a new therapeutic target for angioimmunoblastic T-cell lymphoma
Krug A, Mhaidly R, Tosolini M, et al. Dependence on mitochondrial respiration of malignant T cells reveals a new therapeutic target for angioimmunoblastic T-cell lymphoma. (Impact factor: 5.8)
Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis
Andrews JT, Zhang Z, Prasad GVRK, et al. Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis. (Impact factor: 7.1)
Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon
Nana CMM, Tchakounte BDK, Bitye BMZ, et al. Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.
2023
Light-inducible T cell engagers trigger, tune and shape the activation of primary T cells.
Authors: Jaeger M, Anastasio A, Brustlein S, Vincentelli R, Durbesson F, Char R, Boussand M, Lechelon M, Argüello RJ, Marguet D, He HT, Lasserre R. Journal: PNAS (In Press) 2023. Link Impact Factor (IF): 11
A novel inborn error of immunity with biallelic mutations in NFATC1 impairing the CD8+ T-cell function via perturbed glycolysis.
Kostel Ba S, Giuliani S, Block J, Repiscak P, Shahin T, Kasap N, Ransmayr B, Hafemeister C, Miao Y, van de Wetering C, Frohne A, Jimenez Heredia R, Schuster M, Zoghi S, Hertlein V, Thian M, Babayeva R, Bilgic Eltan S, Karakoc Aydiner E, Shaw LA, Chowdhury I, Varjosalo M, Argüello RJ, Farlik M, Ozen A, Serfling E, Dupre L, Halbritter F, Bock C, Hannich JT, Castanon I, Kraakman MJ, Baris S, Boztug K. Journal: Blood 2023. Link Impact Factor (IF): 25.7
A Deeply Quiescent Subset of CML LSC Depend on FAO Yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I.
Chimge NO, Chen MH, Nguyen Cu, Wu X, Garcia Gonzalez P, Ogana H, Hurwitz S, Teo JL, Chen X, Jin V, Du J, Kim YM, Ono M, Argüello RJ, Michael Kahn. Journal: Current Mol. Pharmacology 2023. Impact Factor (IF): 4
2022
Distinct Metabolic States Guide Maturation of Inflammatory and Tolerogenic Dendritic Cells.
Authors: Adamik J, Munson P, Hartmann FJ, Combes AJ, Pierre P, Krummel MF, Bendall SC, Argüello RJ*, Butterfield LH*.(*co-last) Journal: Nature Communications 2022. Link Impact Factor (IF): 14.9
OXPHOS Promotes Apoptotic Resistance and Persistence in T-H17 cells.
Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Li Z, Xie Y, Zhang L, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Costas A. Lyssiotis. Journal: Science Immunology 2022. Link Impact Factor (IF): 17.7
Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19.
Maher AK, Burnham KL, Jones E, Tan MMH, Saputil RC, Baillon L, Selck C, Giang N, Argüello RJ, Pillay C, Thorley, E, Short CE, Quinlan R, Barclay WS, Cooper N, Taylor GP, Davenport EE, Dominguez-Villar M. Journal: Nature Communications 2022. Link Impact Factor (IF): 14.9
Dysfunctional subsets of CD39+ T cells, distinct from PD-1+, driven by leukemic extracellular vesicles in myeloid leukemias.
Swatler J, Lo Tartaro D, Borella R, Brewinska-Olchowik M, Paolini AM, Neroni A, Turos-Korgul L, Wiech M, Kozlowska E, Cysewski D, Grabowska-Pyrewicz W, Wodjda U, Basak G, Argüello RJ, Cossarizza A, De Biasi S, Piwocka K. Journal: Haematologica 2022. Link Impact Factor (IF): 11
Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases.
Michaudel C, Danne C, Agus A, Magniez A, Aucouturier A, Spatz M, Lefevre A, Kirchgesner J, Rolhion N, Wang Y, Lavelle A, Galbert C, Da-Costa G, Poirier M, Lapiere A, Planchais J, Nádvorník P, Illes P, Oeuvray C, Michel ML, Benech N, Bourrier A, Nion-Larmurier A, Landman C, Richard ML, Emond P, Seksik P, Beaugerie L, Argüello RJ, Moulin D, Mani S, Dvorák Z, Bermúdez-Humarán LG, Langella P, Sokol H. Journal: Gut 2022. Link Impact Factor (IF): 31.8
Unravelling the sex-specific diversity and functions of adrenal gland macrophages
Dolfi B, Gallerand A, MM Firulyova, Y Xu, J Merlin, A Dumont, A Castiglione, N Vaillant, S Quemener, H Gerke, MI. Stunault, PR Schrank, SH Kim, A Zhu, J Ding, J Gilleron, V Magnone, P Barbry, D Dombrowicz, C Duranton, A Wakkach, C Blin-Wakkach, B Becher, S Pagnotta, Argüello RJ, P Rantakari, S Chakarov, F Ginhoux, K Zaitsev, KW Kim, LY Charvet, RR Ginamard, JW Williams, S Ivanov. Journal: Cell Reports 2022. Link Impact Factor (IF): 9.4
ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection.
Corral D, Charton A, Krauss MZ, Blanquart E, Levillain F, Lefrançais E, Sneperger T, Girard J-P, Eberl G, Poquet Y, Guéry JC, Argüello RJ, Belkaid Y, Hepworth MR, Neyrolles O, Hudrisier D. Journal: Cell Reports 2022. Link Impact Factor (IF): 9.4
A toolbox to profile immunometabolism tested in macrophages.
Verberk SGS, de Goede KE, Gorki FS, van Dierendonck X, Argüello RJ, Van den Bossche J. Journal: Cell Reports Methods 2022. Link Impact Factor (IF): 10.6Journal: Cell Reports 2022. Link Impact Factor (IF): 9.4
2021
Mitochondrial inhibitors circumvent adaptive resistance to venetoclax and cytarabine combination therapy in acute myeloid leukemia.
Bosc C, Saland E, Bousard A, Gadaud N, Sabatier M, Cognet G, Farge T, Boet E, Gotanègre M, Aroua N, Mouchel PL, Polley N, Larrue C, Kaphan E, Argüello RJ, Mazzotti C, Avet-Loiseau, Vergez F, Tamburini J, Fournié JJ, Tion IS, Wei AH, Kaoma T, Marine JC, Récher C, Stuani L, Joffre C, Sarry JE. Journal: Nature Cancer 2021. Link Impact Factor (IF): 24
Distinct metabolic programmes control the effector fate of γδ T cell subsets and their activities in the tumour microenvironment.
Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Agudelo L, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville S, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B*, Pennington DJ*, Lynch L*. Journal: Nature Immunology 2021. Link Impact Factor (IF): 27
2020
SCENITH: A flow cytometry-based method for functional profiling energy metabolism with single cell resolution.
Argüello RJ@*, Combes AJ, Char R, Bousiquot E, Gigan JP, Camosseto V, Samad B, Tsui J, Yan P, Boissonneau S, Figarella-Branger D.F, Tabouret E, Gatti E, Krummel MF, Pierre P. Journal: Cell Metabolism 2020. Link Impact Factor (IF): 31